CA' CORNARO-GHELTOF, probably built in the late 1500s, stands on the Grand Canal between Ca' Mocenigo Nuova on the right and several low and undistinguished buildings on the left.

In Palaces and Churches on the Grand Canal in Venice, Umberto Franzoi comments (p. 103), "Flanked by lateral single-lights with framed arches, the central three-light section on the first piano nobile is of the Serliana type. The width of this Serliana section is respected in the interesting four-light section stating the central reception hall on the second storey."

The courtyard of the structure, featuring an open staircase and a Gothic-style facade, is highlighted by a 10th century Byzantine-Gothic well-head.